// clear the background
Graphics g = this.CreateGraphics();
g.Clear(Color.AliceBlue);
// create a pen
Pen pen = new Pen(Color.Red, 1f);
// the string to be drawn
string s = "S";
// the first font
Font f1 = new Font("Arial", 10f);
float strWidth1 = g.MeasureString(s, f1, 500, System.Drawing.StringFormat.GenericTypographic).Width;
float fontHeight1 = f1.GetHeight(g);
float fontAscentHeight1 = (fontHeight1/f1.FontFamily.GetLineSpacing(f1.Style))*f1.FontFamily.GetCellAscent(f1.Style);
// the second font
Font f2 = new Font("Arial", 48);
float fontHeight2 = f2.GetHeight(g);
float fontAscentHeight2 = (fontHeight2/f2.FontFamily.GetLineSpacing(f2.Style))*f2.FontFamily.GetCellAscent(f2.Style);
// draw the base line
Point ptStart = new Point(0, this.ClientSize.Height/2);
Point ptEnd = new Point(this.ClientSize.Width, this.ClientSize.Height/2);
g.DrawLine(Pens.Black, ptStart, ptEnd);
// draw string with first font
g.DrawString(s, f1, Brushes.Red, new PointF(0, ptStart.Y - fontAscentHeight1), System.Drawing.StringFormat.GenericTypographic);
// draw string with second font
g.DrawString(s, f2, Brushes.Red, new PointF(strWidth1, ptStart.Y - fontAscentHeight2), System.Drawing.StringFormat.GenericTypographic);