Delivering highly accurate long reads to drive discovery in life science

DELIVERING HIGHLY ACCURATE LONG READS TO DRIVE DISCOVERY IN LIFE SCIENCE

What is SMRT Sequencing?

Single Molecule, Real-Time (SMRT) Sequencing is the core technology powering our long-read sequencing platforms. This innovative approach was the first of its kind and is now a proven technology used in all fields of life science.

Learn how to go from DNA to discovery with SMRT Sequencing in this short video.

 

Original Publication: Eid, J., et al. (2009) Real-time DNA sequencing from single polymerase molecules. Science, 323(5910), 133–138.

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What are the Advantages of SMRT Sequencing?

 

Long Reads

 

With reads tens of kilobases in length you can readily assemble complete genomes and sequence full-length transcripts.

Explore the benefits of long reads

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High Accuracy

 

Sequencing free of systematic error achieves >99.999% consensus accuracy.

Learn more about high accuracy

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Uniform Coverage

 

No bias based on GC content means you can sequence through region inaccessible to other technologies.

Discover how uniform coverage lets you see more

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Single-Molecule Resolution

 

Capturing sequence data from native DNA or RNA molecules enables highly accurate long reads with >99% single-molecule accuracy.

See the difference single-molecule resolution makes

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Epigenetics

 

With no PCR amplification step, base modifications are directly detected during sequencing.

Get more from your sequencing with epigenetics

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What Can You Do With SMRT Sequencing?

Explore the full range of SMRT Sequencing applications.

 

	Whole Genome Sequencing   For humans, plants, animals and microbes including de novo assembly and variant detection		Complex Populations   Understand variants among bacterial, viral and cancer cell populations
	RNA Sequencing   In-depth analysis of cDNA sequences across the entire transcriptome or targeted genes		Epigenetics   Detect DNA modifications in your samples while you sequence on the PacBio platform
	Targeted Sequencing   Study relevant genome targets across any regions of interest