tinymce.PluginManager.add("upfile", function (e) {
    var t = e.settings;    
    e.addCommand("InsertUpFile", function () {
        e.windowManager.open({
            title: "上传图片",
            width:parseInt(e.getParam("plugin_upfile_width", "300"), 10),
            height: parseInt(e.getParam("plugin_upfile_height", "100"), 10),
            html: '<div style="margin:10px"><select name="filepath"><option value="product">产品图片</option><option value="friendship">友情链接</option><option value="decorate">装修图片</option><option value="other">其他</option></select><br /><br /><input id="TinymcefileToUpload" type="file"  name="TinymcefileToUpload" class="input"></div>',
            buttons: {
                    text: "上传",
                    onclick: function () {                        
                        $.ajaxFileUpload
                        (
                            {
                                url: '/Admin/Index/UpFile?Path=' + $("select[name='filepath']").val(),//修改成您的地址就可以了
                                secureuri: false,
                                fileElementId: 'TinymcefileToUpload',
                                dataType: 'json',
                                beforeSend: function () {
                                    $("#loading").show();
                                },
                                complete: function () {
                                    $("#loading").hide();

                                },
                                success: function (data, status) {
                                    if (typeof (data.error) != 'undefined') {
                                        if (data.error != '') {
                                            alert(data.error);
                                        } else {                                           
                                            e.execCommand("mceInsertContent", !1, "<img src=" + data.msg + ">");
                                            
                                        }
                                    }
                                },
                                error: function (data, status, e) {
                                    alert(data);
                                    alert(e);
                                }
                            }
                        )
                        this.parent().parent().close();
                        
                    }
           
            }
        })
    }), e.addButton("upfile", {
        icon: "image",
        tooltip: "上传图片",
        cmd: "InsertUpFile"
    }), e.addMenuItem("upfile", {
        icon: "image",
        text: "上传图片",
        cmd: "InsertUpFile",
        context: "insert"
    });
});

 需要引用"ajaxfileupload"jquery上传文件插件。