mysqlnd cannot connect to MySQL 4.1+
phpMyAdmin - error
#2000 - mysqlnd cannot connect to MySQL 4.1+ using the old insecure authentication. Please use an administration tool to reset your password with the command SET PASSWORD = PASSWORD('your_existing_password'). This will store a new, and more secure, hash value in mysql.user. If this user is used in other scripts executed by PHP 5.2 or earlier you might need to remove the old-passwords flag from your my.cnf file
mysql -u root –p
use mysql;
set old_passwords=0;
update user set password=PASSWORD('222222')
SELECT LENGTH(PASSWORD) FROM USER;
FLUSH PRIVILEGES;