longitudinal models | 纵向研究 | mixed model
A longitudinal study refers to an investigation where participant outcomes and possibly treatments or exposures are collected at multiple follow-up times.
纵向研究是指在多个跟随时间点下收集参与者结果和可能的治疗/状况下的调查。
Using R and lme/lmer to fit different two- and three-level longitudinal models
random effects- 随机效应
fixed effect - 固定效应
Fixed Effects vs Random Effects
标准的统计建模及评估的步骤:
- 了解要分析的数据;
- 明确分析的目的;
- 选择合适的模型;
- 不同模型的评估;
1. 了解要分析的数据;
ALSPAC data - Explore data and samples
重点关注的指标:
age
sex
PGS
BMI
2. 明确分析的目的;
BMI ~ age + age2 + sex + pgsC + pgsM + mBMI and interaction of each with age, age2, and sex
3. 选择合适的模型;
GLMM
4. 不同模型的评估;
AIC
BIC
待续~