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#region 禁用关闭按钮
[DllImport("USER32.DLL", CharSet = CharSet.Unicode)]
private static extern IntPtr GetSystemMenu(IntPtr hWnd, UInt32 bRevert);
[DllImport("USER32.DLL ", CharSet = CharSet.Unicode)]
private static extern UInt32 RemoveMenu(IntPtr hMenu, UInt32 nPosition, UInt32 wFlags);
private const UInt32 SC_CLOSE = 0x0000F060;
private const UInt32 MF_BYCOMMAND = 0x00000000;

private void MainWindow_Loaded(object sender, RoutedEventArgs e)
{
    var hwnd = new WindowInteropHelper(this).Handle;  //获取window的句柄
    IntPtr hMenu = GetSystemMenu(hwnd, 0);
    RemoveMenu(hMenu, SC_CLOSE, MF_BYCOMMAND);
}
#endregion
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将此段代码放到WPF窗口的加载事件中，可以让WPF窗口标题中的关闭按钮禁用

但任务栏中缩略图的关闭按钮不会禁用(这应该是微软的bug)