UniFrac
https://mothur.org/wiki/Unifrac.unweighted
The unifrac.unweighted comand implements the unweighted UniFrac algorithm. The unifrac.weighted command implements the weighted version of the command. Both of these methods are available through the UniFrac website. The UniFrac methods are generic tests that describes whether two or more communities have the same structure. The significance of the test statistic can only indicate the probability that the communities have the same structure by chance. The value does not indicate a level of similarity. The files that we discuss in this tutorial can be obtained by downloading the AbRecovery.zip file and decompressing it.