KeyEvent

public partial class Form1 : Form{
        public Form1()
        {
            InitializeComponent();
            this.KeyUp += new System.Windows.Forms.KeyEventHandler(deal_key);  //register
        }

        private void deal_key(object sender, System.Windows.Forms.KeyEventArgs e)
        {
            if (e.Control && e.KeyCode == Keys.R)
                //process here       

        }

}